diabetes
Pathways
Studies (5)
Effects of Niacin and Vitamin C on Blood Sugar
Rats in group 1 received no treatment. Rats in group 2 received daily 100 mg/kg body weight niacin injections. Rats in group 3 received daily 50 mg/kg body weight vitamin C injections. Rats in group 4 received both niacin and vitamin C injections. Blood sugar levels were measured before and after treatment. The results showed that niacin and vitamin C both lowered blood sugar levels in normal rats. Niacin was more effective than vitamin C in lowering blood sugar levels in diabetic rats. The combination of niacin and vitamin C was the most effective in lowering blood sugar levels in diabetic rats.
Studies on Tryptophan-Niacin Metabolism in Streptozotocin Diabetic Rats
Rats where split into 2 groups, one group was injected with a single does of streptozotocin at a dose of 60 mg/kg body weight, which is a chemical that is used to induce diabetes. After 12 weeks it was found that the diabetes group was only able to convert half as much tryptophan to niacins as the control group. The rats in the diabetic group had twice the excretion of xanthurenic acid in their urine. Xanthurenic acid is a waste product that is produced when tryptophan is not converted into niacin.
Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials
Review of many clinical trials concludes niacin supplementation can improve lipid profiles without affecting the glycemic levels for patients with Type 2 diabetes.
Effect of pharmacological doses of niacin on testicular structure and function in normal and diabetic rats
Feeding normal and diabetic rats 800mg of niacin per kg of diet increased testicular weight in all rats and decreased testicular MDA (a biomarker for cancer). Normal rats, but not diabetic ones, also had an increase in sperm count and serum testosterone.
Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Studies show that melatonin ameliorates hyperinsulinemia, insulin resistance, and insulin sensitivity.