NADPH
Studies (7)
Dietary nicotinic acid supplementation improves hepatic zinc uptake and offers hepatoprotection against oxidative damage
In rats, supplementing with high levels of nicotinic acid in diet before experiencing cell damage (induced by tert-butyl hydroperoxide injections) helped protect the liver, preserving its normal structure and improving its ability to absorb zinc, a beneficial element. This effect was less pronounced if the NA was increased after the cell damage had occurred. Rats with a deficiency of nicotinic acid in their diet exhibited the highest level of liver damage.
Effect of pharmacological doses of niacin on testicular structure and function in normal and diabetic rats
Feeding normal and diabetic rats 800mg of niacin per kg of diet increased testicular weight in all rats and decreased testicular MDA (a biomarker for cancer). Normal rats, but not diabetic ones, also had an increase in sperm count and serum testosterone.
Protective effects of niacin against methylmercury-induced genotoxicity and alterations in antioxidant status in rats
Rats being poisoned with methylmercury have less adverse effects when their diet is supplemented with niacin (50md/day).
Melatonin protects human red blood cells from oxidative hemolysis: new insights into the radical-scavenging activity
Red blood cells exposed to oxidative stress will consume melatonin and use it for protect against deterioration.
Open AccessReview Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical Aspects
Overview of how niacin and its metabolites like NAD, NADP, NADPH play a key role in cellular signaling, apoptosis, balancing intestinal flora and gene expression. Without external supply of supply of niacin, the genome becomes unstable via the antioxidant system no longer functioning efficiently, which ultimately leads to cell death.
The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis
Talks about how intracellular niacin depletion along leads to tryptophan depletion as the body attempts to compensate by synthesizing niacin from tryptophan. And how this imbalance impairs the immune system in HIV.
A novel treatment target for Parkinson's disease
The GPR109A receptor and its agonists (niacin and butyrate) have anti-inflammatory actions in the skin, gut and retina. For Parkinson's disease, niacin supplementation may have 3 benefits: lower inflammation via GPR109A-related mechanisms, increase dopamine production in brain by supplying NADPH and boosting mitochondrial functions by increasing the NAD/NADH ratio.