DNA-repair
Pathways
Studies (9)
Protective effects of niacin against methylmercury-induced genotoxicity and alterations in antioxidant status in rats
Rats being poisoned with methylmercury have less adverse effects when their diet is supplemented with niacin (50md/day).
Impact of Nuclear De Novo NAD+ Synthesis via Histone Dynamics on DNA Repair during Cellular Senescence To Prevent Tumorigenesis
The de novo production of NAD+ in the cell nucleus is central to the DNA repair capacity of aging cells and thus against preventing tumors.
Prevention of Cancer by Vitamin B3 (Nicotinamide and Nicotinic Acid)
Nicotinamide, Nicotinic acid (niacin) and the related aromatic amides have been shown to have striking indications of possessing anticarcinogenic properties.
Oral niacin prevents photocarcinogenesis and photoimmunosuppression in mice
Mice subjected to high dose ultraviolet light for about 6 months while fed a diet supplemented with 0%, 0.1%, 0.5%, or 1.0% (by dry weight of feed) of niacin showed 68%, 60%, 48%, and 28% rates of skin cancer respectively, indicating a protective effect. Elevated levels of NAD found in niacin supplemented mice. NAD modulates the function of DNA strand scission surveillance proteins p53 and poly(ADP-ribose) polymerase, two proteins critical in cellular responses to UV-induced DNA damage.
High dietary niacin intake is associated with decreased chromosome translocation frequency in airline pilots
Statistical analysis of 82 airline pilots showed a 42 % decrease in the frequency of chromosome translocations (ie DNA damage from higher rates of ionizing radiation while flying) for those with high compared with low dietary niacin.
Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway
Feeding rabbits Niacin up-regulated SIRT1 expression, which is involved with DNA repair. Rabbits where then subjected to stress via a collar on an artery in their neck and it was shown that niacin protects against blood vessel inflammation via the SIRT1/CD40-dependent signaling pathway.
Niacin requirements for genomic stability
Niacin involved with over 400 NAD+ dependent reactions. Essentially all cancer patients are deficient in niacin. Exposing mice to high levels of UVB radiation to induce skin cancer showed that mice on the highest doses of niacin had the lowest rate of skin cancer at 28% compared to 68% in the control group.
The NAD + precursor nicotinic acid improves genomic integrity in human peripheral blood mononuclear cells after X-irradiation
Peripheral blood mononuclear cells (diverse mix of highly specialized immune cells) supplemented with nicotinic acid (niacin) and then blasted by x-ray radiation showed increased NAD+ levels, improved DNA repair efficiency and enhanced genomic stability compared to control.
Pharmacological Intakes of Niacin Increase Bone Marrow Poly(ADP-Ribose) and the Latency of Ethylnitrosourea-Induced Carcinogenesis in Rats
Rats fed high niacin diet and then poisoned with ethylnitrosourea (a potent mutagen) survived for longer and had increase amounts of NAD+ (1-1.5x) and ADP-ribose in their bone marrow.