p53
Studies (5)
Impact of Nuclear De Novo NAD+ Synthesis via Histone Dynamics on DNA Repair during Cellular Senescence To Prevent Tumorigenesis
The de novo production of NAD+ in the cell nucleus is central to the DNA repair capacity of aging cells and thus against preventing tumors.
Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism
Curcumin is an anticancer agent, it has demonstrates potent anti-proliferative activity in a wide range of cancer cells, including liver, breast, lung, stomach, colon, prostate, head and neck cancers. This study modified curcumin by adding 2 niacins molecules to it to make Curcumin Nicotinate. They tested it out on some cancer cell cultures and it showed that the Curcumin Nicotinate improved the anti cancer effect of curcumin by improving its cell selectivity.
Prevention of Cancer by Vitamin B3 (Nicotinamide and Nicotinic Acid)
Nicotinamide, Nicotinic acid (niacin) and the related aromatic amides have been shown to have striking indications of possessing anticarcinogenic properties.
Oral niacin prevents photocarcinogenesis and photoimmunosuppression in mice
Mice subjected to high dose ultraviolet light for about 6 months while fed a diet supplemented with 0%, 0.1%, 0.5%, or 1.0% (by dry weight of feed) of niacin showed 68%, 60%, 48%, and 28% rates of skin cancer respectively, indicating a protective effect. Elevated levels of NAD found in niacin supplemented mice. NAD modulates the function of DNA strand scission surveillance proteins p53 and poly(ADP-ribose) polymerase, two proteins critical in cellular responses to UV-induced DNA damage.
Niacin requirements for genomic stability
Niacin involved with over 400 NAD+ dependent reactions. Essentially all cancer patients are deficient in niacin. Exposing mice to high levels of UVB radiation to induce skin cancer showed that mice on the highest doses of niacin had the lowest rate of skin cancer at 28% compared to 68% in the control group.