NF-kB
Pathways
Studies (24)
Relationship between dietary niacin intake and erectile dysfunction: a population-based study
A large U.S. study found men with higher dietary niacin (vitamin B3) intake had a lower risk of erectile dysfunction (ED). Men in the highest third of niacin intake were 56% less likely to have ED compared to those in the lowest third. This link held true even after accounting for other factors like age, weight, and health conditions.
Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain
Summary of GPR109A (niacin receptor) role in inflammation of the nervous system, especially the brain, and how activation of GPR109A plays a role in healing may conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and pathological pain.
A comparison of the efficacy and toxic effects of sustained vs immediate-release niacin in hypercholesterolemic patients
The effects on cholesterol of modified "sustained release" niacin was compared to immediate release niacin (aka nicotinic acid) and showed that sustained release tends to lower LDL more, while immediate release raises HDL more at all dosage levels. The key takeway though is that 52% of the patients taking sustained release developed signs of liver toxixity, while 0% of the ones taking immediate release did.
Niacin regresses collagen content in human hepatic stellate cells from liver transplant donors with fibrotic non-alcoholic steatohepatitis (NASH)
Taking niacin ~1-3g daily clears up liver collagen and fat deposits which are associated with liver disease. It also prevents them from forming.
Action of nicotinic acid on the reversion of hypoxic-inflammatory link on 3T3-L1 adipocytes
Niacin reduces inflammation caused by low levels of oxygen in tissue that is associated with obesity.
NAD+ homeostasis in human health and disease
In depth review of NAD+, how its made in the human body, how it becomes deficient, and how its deficiency is a causal factor of a wide range of diseases. And how boosting NAD+ via enhancing agents like niacin ( especially niacin since it is the primary, so called Preiss-Handler pathway of manufacture ) can help cure a wide range of diseases.
Effect of Different Levels of Niacin on Serum Biochemical Parameters, Antioxidant Status, Cytokine Levels, Inflammatory Gene Expression and Colonic Microbial Composition in Weaned Piglets
Piglets separated from their mother in agriculture tend to struggle health wise. Supplementing their diet with niacin significantly improves their survivability via factors like improved colonic microbial diversity, intestinal health, reduced intestinal inflammation and improved overall immunity.
Treatment of Arthritis by Nicotinic Acid and Nicotinamide
Reports of patients successfully managing or curing various forms of arthritis via nicotinic and/or nicotinamide supplementation. A daily dosage of about one gram per 50 lb. body weight is necessary.
Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages
Many of the beneficial and adverse effects of niacin are mediated via GPR109, which is highly expressed in adipose tissue and macrophages. Multiple infectious and inflammatory stimuli stimulate GPR109A expression in adipose tissue and in macrophages.
Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection
Many microbial metabolites, especially butyrate, found in the intestinal flora, are extremely important in regulating systemic and pulmonary immune and inflammatory responses and have a wide range of anti-inflammatory and immunity enhancing functions. Improving intestinal micro-ecology via like butyrate supplementation may partially mediate the effects of SARS-CoV-2 on the both local gastrointestinal response and systemic immune response of the host, and thus be a target for COVID-19 prevention and treatment.
Melatonin supplementation ameliorates myocardial connexin-43 disorders and arrhythmia risk of hypertensive and obese rats
Melatonin supplementation benefits male hypertensive and female obese rats due to suppression of metabolic disorders and lethal arrhythmia risk. Arrhythmia is a problem with the rate or rhythm of your heartbeat. Protection against arrhythmia may attributed, at least in part, to up-regulation of myocardial Cx43, which is a protein that is essential for the formation of heart structures.
The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
Single-center, open-label, randomized clinical trial done on Covid patients in Iraq to study melatonin supplementation for Covid treatment. All 158 patients got standard care, 82 of those patients ate 10mg melatonin each night. Thrombosis and sepsis developed significantly less in melatonin group. 13 patients in control group died vs 1 person in the melatonin group.
Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms
Explores protective effect of niacin on lung tissue by dosing mouse lung white blood cells with niacin and exposing them to inflammatory toxins (Lipopolysaccharides). This demonstrated strong anti-inflammatory effects of niacin ( reduced levels of TNF-α, IL-6 and IL-1β) and that the protective effect depends on expression of GPR109A.
Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathway
Rats injected with e coli bacteria to induce lung inflammation survived better with high dose (~1% of diet) niacin supplementation. The reduced lung inflammation and damage was associated with downregulation of the NF-κB (Nuclear Factor Kappa B) pathway.
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
Adipose tissue (body tissue used for the storage of fat) is major site of action for niacin. When adding a white blood cell attractant to adipose tissue, niacin suppresses the pro-atherogenic (plaque inducing) chemokines and upregulates the atheroprotective (protective against plaque and improves metabolism of sugar) adiponectin.
The COVID-19 Burden or Tryptophan Syndrome: Autoimmunity, Immunoparalysis and Tolerance in a Tumorigenic Environment
Long covid is due to changes in the metabolism of tryptophan and the lack of niacin (NAD/NADH+). Tryptophan has its metabolism altered by the lack of intestinal absorption due to internalization of ACE-2 and hypoxemia and inflammation, diverting its products to the formation of toxic Kynurenine metabolites. The longer time under hypoxemia, the less niacin and the more tryptophan will deviate to Kynurenine in an inflamed environment
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets
Computer modeling shows niacin a key to therapy for covid via enhancing the immune system, inhibiting inflammation and regulating cellular microenvironment.
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
Supplementing melatonin is safe. Melatonin is a potent anti-oxidant and anti-inflammatory agent, it's found in all cells and can easily cross all physiological barriers in body. Melatonin levels decreases with age. Melatonin therapy looks promising for a wide range of health issues in newborn babies.
Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway
Feeding rabbits Niacin up-regulated SIRT1 expression, which is involved with DNA repair. Rabbits where then subjected to stress via a collar on an artery in their neck and it was shown that niacin protects against blood vessel inflammation via the SIRT1/CD40-dependent signaling pathway.
Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications
In depth review of how niacin and its metabolites play a key role in brain and nerve health. Alzheimers and Niacin intake are inversely correlated. Niacin helps cells stay alive when blood supply is cutoff.
Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway
Supplementing mice with melatonin increases butyrate production in their gut via bacteria, conversely antibiotics severely impair this butyrate production. When mice are poisoned with titanium nanoparticles to induce bone deterioration, butyrate has a protective effect against bone loss. This protective effect is specifically dependent on the GPR109A receptor that seems to be activated by the butyrate enriched gut microbiota.
Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
GPR109A (aka HCA2) is highly expressed in immune cells and together with niacin seems to inhibit proinflammatory aspects of immune cell activity.
Periodontitis and intake of thiamine, riboflavin and niacin among Korean adults
Low niacin in diet leads to higher (~125%) rates of severe gum infection.
Niacin and its metabolites as master regulators of macrophage activation
The focus is on how niacin and its metabolites enable white blood cells to react to a changing microenvironment (macrophage plasticity). It also discusses the anti-oxidant and anti-inflammatory aspects of niacin.