alzheimers
Studies (4)
Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain
Summary of GPR109A (niacin receptor) role in inflammation of the nervous system, especially the brain, and how activation of GPR109A plays a role in healing may conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and pathological pain.
Effect of Huntington's and Alzheimer's diseases on the transport of nicotinic acid or nicotinamide across the human blood-brain barrier
Looked into how niacin and nicotinamide cross blood brain barrier in control, Huntington & Alzheimer patients. Nicotinamide had higher uptake in brain tissue than niacin. No statistical difference in concentrations across the groups. It was observed that niacin and nicotinamide concentrated in red blood cells vs plasma over time.
Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders
Melatonin plays a key role in intracellular membrane integrity, especially when a cell is in under stress. Melatonin plays role in maintaining a high ATP:ADP ratio, which suppresses glycolysis. Supplemental melatonin shown to accumulate in all cells, accumulates 10x in membrane compared to mitochondria. Plays unique role in fat/water interfaces, as it can combine with both. Biomolecular condensates play a big role in brain disorders and are shaped by complex relationships between membraneless organelles, membranes/lipid rafts, ATP, RNA, and most of all, stress. Melatonin's intimate association with each of these decisive influencers may position it as an important mediator of sorting out of these condensates in health and disease via ATP-dependent mechanisms.
Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications
In depth review of how niacin and its metabolites play a key role in brain and nerve health. Alzheimers and Niacin intake are inversely correlated. Niacin helps cells stay alive when blood supply is cutoff.