prostaglandin
Pathways
Studies (8)
Niacin ameliorates ulcerative colitis via prostaglandin D2‐mediated D prostanoid receptor 1 activation
Out of 26 patients with moderate ulcerative colitis (inflammation of the colon) who were unresponsive to conventional treatments, 92.3% responded positively and 88.5% went into remission after receiving a daily niacin enema treatment for 6 weeks. The had no serious side effects, showed notable improvements in intestinal healing, reduced symptoms like rectal bleeding and stool frequency. Niacin is a promising, well-tolerated alternative for inducing clinical remission of ulcerative colitis.
Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain
Summary of GPR109A (niacin receptor) role in inflammation of the nervous system, especially the brain, and how activation of GPR109A plays a role in healing may conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and pathological pain.
Treatment of Asthma by Nicotinic Acid
Relief of the asthma attacks was obtained in 21 out of 30 cases with niacin either via intravenous injection (16 out of 21 patients relieved) or orally (5 out of 9 patients relieved). A series of 50 or 100 mg doses used. Relapse was common once niacin was discontinued.
Antiatherothrombotic effects of nicotinic acid
Niacin reduces blood viscosity through a variety of mechanisms, thus improving blood flow and perfusion through choke points of the vasculature. Finally, niacin has cardioprotective effects that may limit ischemia–reperfusion injury. By preserving glycolysis during periods of inadequate blood supply and improving blood flow to the heart after a stroke, niacin can improve the functional recovery of the muscular tissue of the heart.
Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels
NA activates the capsaicin receptor TRPV1 by lowering the activation threshold for heat, causing channel activation at physiological body temperature. Conversely it inhibits TRPV4 by raising activation temp to above body temp, ~41 celsius. Overall, the effects on TRPV1 and TRPV3 are potentiating while those on TRPV2 and TRPV4 are inhibitory. Little is known about the detailed structures of TRPV2-4. The TRPV receptors play a role in the flushing response.
Melatonin Treats H Pylori and Gastric Ulcers
In various studies where patients are treated for gastric ulcers, those on melatonin did better.
The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature
An overview of the evidence for using niacin to treat headaches. Mechanisms explored are vasodilation, improvement of mitochondrial energy metabolism, improved oxygenation, lowering of lactic acid.
Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages
When mice are induced with pulmonary hypertension via drugs and low oxygen, those on niacin have less severe outcomes, due to enhanced macrophage activity and release of PGD2.