adiponectin
Studies (8)
Intravenous Niacin Acutely Improves the Efficiency of Dietary Fat Storage in Lean and Obese Humans
24 healthy men and women with a mean age of 35 years, where injected Intravenously w/ 1g of niacin or placebo for 2 weeks. The niacin group ended up with acutely lower levels of FFAs (free fatty acids, fats floating around in the bloodstream) and significantly higher levels of triglyceride stored in visceral adipose tissue. This may help to reduce the amount of fat that is stored in the liver and other organs, which can help to improve insulin sensitivity and reduce the risk of metabolic complications. IE niacin may help people with diabetes and obesity to lose weight and improve their health.
Nicotinic Acid Treatment Shifts the Fibrinolytic Balance Favourably and Decreases Plasma Fibrinogen in Hypertriglyceridaemic Men
23 hypertriglyceridaemic men took 4g/day of niacin for 6 weeks and saw very significant improvements in lipoprotein concentrations (reducing very low density cholesterol and triglycerides by ~50%) as well as reduced blood clotting and thrombosis factors.
Niacin reduces abdominal fat: pilot study
Participants in an open label study at Kaiser Permanente in San Francisco supplemented ~3g niacin a day. After about 1 year, 81% of patients had an by an average reduction of 27% in intra-abdominal fat. The degree of fat loss was associated with the degree of increase in HDL cholesterol and a reduced Total Cholesterol/HDL cholesterol ratio.
Action of nicotinic acid on the reversion of hypoxic-inflammatory link on 3T3-L1 adipocytes
Niacin reduces inflammation caused by low levels of oxygen in tissue that is associated with obesity.
Anti-inflammatory effects of nicotinic acid
Niacin has multi-faceted anti inflammatory properties that act in both localized and systemic ways. A major area of its activity is in tissue related to fat storage via the GPR109A receptor. Dosing cells with TNF-alpha ( an inflammatory substance ) showed that niacin treated cells increased the atheroprotective hormone adiponectin and reduced macrophage chemotaxis
Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models
Rats where given unlimited access to food and a controlled amount of exercise. Those taking niacin + melatonin lost statistically significantly more weight, compared to control, niacin only and melatonin only groups. Suggests a synergy between niacin & melatonin supplementation for anti-obesity. It's noted that mice lacking the niacin receptor GPR109A had progressive weight gain and liver fat accumulation.
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
Adipose tissue (body tissue used for the storage of fat) is major site of action for niacin. When adding a white blood cell attractant to adipose tissue, niacin suppresses the pro-atherogenic (plaque inducing) chemokines and upregulates the atheroprotective (protective against plaque and improves metabolism of sugar) adiponectin.
New Perspectives on the Use of Niacin in the Treatment of Lipid Disorders
An overview of research showing supplementing niacin lowers the risk of heart attack frequency and severity.